Free Radicals in Chemistry, Biology and MedicineFREE RADICALS IN CHEMISTRY, BIOLOGY AND MEDICINE

Edited by Toshikazu Yoshikawa, Shinya Toyokuni,
Yorihiro Yamamoto, Yuji Naito
Published 2000, Hardback/Cloth, Number of pages 580
OICA International: London
ISBN 1 903063 04 3
Price 90
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Cat. No. 2006


Chapter 1:

Protein tyrosine nitration by peroxynitrite:Role of selenium in protection

Chapter 2:

Lipid peroxidation-dependent mutagenesis: Chemistry and biology.

Chapter 3:

Biological significance of formation of 4-hydroxynonenal from lipid peroxidation

Chapter 4:

Advanced lipid peroxidation end products.

Chapter 5:

Chemistry of long range oxidative DNA damage and design of hole trap

Chapter 6:

. Oxidative damage to DNA : Measurement and biological role

Chapter 7:

Oxidative DNA damage; Product formation and repair by base-excision pathway

Chapter 8:

Analysis of 8-hydroxydeoxyguanosine in cellular DNA and urine. Marker of oxidative stress

Chapter 9:

Role of Sequence-specific DNA damage in carcinogenesis and Aging

Chapter 10:

Modifications of DNA, RNA and proteins by interactions of NO, O2.- and HOCl

Chapter 11:

Protein-centred radical(s) of mitochondrial cytochrome c oxidase.

Chapter 12:

Detection of O2.- formation from nitric oxide synthases using ESR spin-trapping technique

Chapter 13:

Possible deferoxamine toxicity derived from Its oxidative decomposition



Chapter 14:

Positive and negative modulation of NF-kB activity by environmental stress

Chapter 15:

Signalling for the synthesis of glutathione.

Chapter 16:

Mammalian selenium-dependent thioredoxin reductase

Chapter 17:

Redox regulation of gene expression in mitogen-activated T lymphocytes

Chapter 18:

Thioredoxin - dependent redox regulation in biological responses

Chapter 19:

Lipid peroxidation and transforming growth factor- expression

Chapter 20:

Cytoprotective mechanisms of nitric oxide; the role of cell signalling

Chapter 21:

UV Protection in marine organisms.I.Sunscreens,oxidative stress and antioxidants

Chapter 22:

UV Protection in marine organisms: Mycosporine-like amino acids.

Chapter 23:

Photooxidative stress and acclimatory mechanisms in plants

Chapter 24:

Radiation induced genotoxic damage in mammalian cells:

Chapter 25:

Some Features of base excision repair and its role in prevention of mutations.

Chapter 26:

The mitochondrial production of free radicals

Chapter 27:

Increased mitochondrial decay and oxidative Stress in the aging rat.

Chapter 28:

Mitochondorial membrane permeability transition and its sensitivity to l-carnitine.

Chapter 29:

Activation of the phagocyte NADPH oxidase: Molecular interaction of oxidase components.

Chapter 30:

Apoptosis and oxidative stress: Promotion, modulation and abrogation

Chapter 31:

OxLDL Modulates the cell cycle via oxidative stress

Chapter 32:

Target genes in oxidative stress-induced cancer.

Chapter 33:

Target genes in oxidative stress-induced cancer



Chapter 34:

Lipoprotein oxidation, antioxidants and atherosclerosis

Chapter 35:

Measurement of isoprostanes to assess oxidant stress status in vivo

Chapter 36:

Redox status of coenzyme Q and regioisomers of cholesteryl linoleate hydro(pero)xides

Chapter 37:

Reducing capacity of biological fluids and tissues

Chapter 38:

Vitamin E and heart disease.

Chapter 39:

Ischemic stress-regulation of cardiomyocyte apoptosis

Chapter 40:

Neutrophil-mediated damage to.cardiac muscles during cardiopulmonary bypass surgery.

Chapter 41:

Role of nitric oxide in inflammatory bowel disease

Chapter 42:

Significance of ROS in kidney disease elucidated by ureic toxins: from uremia to nephrosis.

Chapter 43:

Increased intracellular reactive oxygen species in hemodialysis patients.

Chapter 44:

Lipid peroxidation-mediated synaptic dysfunction and neuronal death in Alzheimer's

Chapter 45: Factors controlling oxidative damege in Alzheimer disease: metals and mitochondria.
Chapter 46:

Vitamin E and diabetic retinopathy.

Chapter 47:

Oxidative stress and type-2 diabetes.

Chapter 48:

Antioxidants and functional food science

Chapter 49:

Phenyl N-tert-butylnitrone as an anti-inflammatory agent - Interleukin-10 induction.

Chapter 50:

Quercetin glucosides as dietary antioxidants in blood plasma

Chapter 51:

Protective role of dietary antioxidants in oxidative stress.

Chapter 52:

Putative role of NFkB in Type I Diabetes and the preventative strategies with Antioxidants.

Chapter 53:

Anoxia/reoxygenation-induced inflammatory response: Role of cellular thiol redox status

Chapter 54: NFkB activation in inflammatory bowel disease.

Readership: Aimed at Research and Development in Academia, Hospitals and Industry. Biochemists, public health professionals, biologists, pharmacologists, oncologists, nutritionists, toxicologists, neurologists and other clinicians, final year undergraduate and postgraduate students and all those interested in the study of free radicals and reactive species.

Commentary by Professor Helmut Sies, President
Society for Free Radical Research International

"It is a special point in time which is represented by this book: The year 2000 brought together scientists from all over the world on the occasion of the Xth Biennial Meeting of the Society for Free Radical Research International (SFRRI), held at Kyoto, Japan, October 16-20. This marks a millennial milestone on the path around the globe from the first of these meetings, held at Brunel University, United Kingdom, in 1982, when the Society for Free Radical Research was founded. Much development and enormous enthusiasm in many scientific fields characterizes these activities, and the current book gives a wonderful example. The science of free radicals spans from chemistry to biology and medicine, and consequently the book is divided into these three sections. It is satisfying to see that many of the researchers of the scientific forefront in these areas present their perspectives.

The book may also represent a special point in the development of our science: the human genome has practically been resolved in 2000, and it is obvious that future tools will include concepts and techniques based on that added knowledge. It is to be hoped that the insight provided from the dedicated work by the authors of the 54 chapters in this book will be of further use in the years to come when exciting new questions can be tackled with novel methodology.

The Society for Free Radical Research International serves as an umbrella for regional societies in all continents, and readers of this book who are not yet members are invited to look at the website: http://www.sfrr.org

Special thanks go to the Editors, Professors Yoshikawa, Toyokuni, Yamamoto and Naito, who did a superb job in compiling these up-to-date reports on free radicals in chemistry, biology and medicine".

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